Fig 1.

Composition of nasopharyngeal microbiome in COAST subjects, and relationship to acute respiratory illness. A, Clustering of microbiomes into microbiome profile groups (MPGs), by relative abundances of ASVs within each sample, as described in the Methods section. The heat in the heatmap represents relative abundance of each ASV (rows, color-coded on the right), arranged by samples (columns) clustered into MPGs (top bar separated by colors of dominant ASV). B, MPG association with respiratory illness, calculated from GEE models with sex, age, and season as covariates. Points (color-coded as per [A]) represent the estimates as natural logarithms of odds ratios (ORs) for association of each MPG with samples from patients with illness versus samples from healthy individualsl, whereas error bars represent 95% CIs for estimates. Numeric results are given in Table E2, A.