Table 2.
Morphologic Scores for LCNEC and NSCLC Cases
| Architecture | Necrosis | Prominent Nucleolia | ||||||
|---|---|---|---|---|---|---|---|---|
| Specimen | Score | Score | Score | |||||
| 0 | 1 | 2 | 3 | 0 | 1 | 0 | 1 | |
| NSCLC, No. (%) | 188 (82) | 38 (16) | 4 (2) | 0 | 170 (74) | 60 (26) | 102 (44) | 128 (56) |
| LCNEC, No. (%) | 3 (14) | 5 (23) | 8 (36) | 6 (27) | 6 (27) | 16 (73) | 14 (64) | 8 (36) |
| Probability | <.0001b | <.0001b | .09 | |||||
LCNEC, large cell neuroendocrine carcinoma; NSCLC, non-small cell lung carcinoma.
aNucleolar prominence was considered in primary analysis but ultimately was excluded from the proposed scoring scheme (Table 1) on the basis of its inability to differentiate between LCNEC and NSCLC.
bStatistically significant (P > .05).