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. 2019 May 29;21(9):1164–1174. doi: 10.1093/neuonc/noz098

Table 2.

Bivariate (unadjusted) analyses for survival

Progression-free Survival Overall Survival
Covariate Hazard Ratio (95% CI) Chi-square P-value Hazard Ratio (95% CI) Chi-square P-value
1p/19q status
1p/19q loss without polysomy
1p/19q loss with polysomy (all) 2.08 (1.52, 2.84) <0.0001 1.52 (0.97, 2.38) 0.07
1p/19q maintenance (all) 3.66 (2.47, 5.42) <0.0001 4.26 (2.63, 6.90) <0.0001
<0.0001 <0.0001
Age 1.02 (1.01, 1.03) 0.0003 1.04 (1.02, 1.05) <0.0001
Sex
Female
Male 1.11 (0.85, 1.45) 0.43 1.10 (0.77, 1.58) 0.60
Pathology diagnosis 1.08 (0.72, 1.61) 0.73 1.15 (1.95, 0.68) 0.60
WHO grade III 2.09 (1.58, 2.78) <0.0001 2.57 (1.70, 3.87) <0.0001
Ki67 1.01 (0.995, 1.02) 0.31 1.01 (0.995, 1.02) 0.20
IDH1/2 mutation 0.76 (0.46, 1.27) 0.30 0.57 (0.24, 1.34) 0.20
Chemotherapy 1.12 (0.85, 1.47) 0.41 0.98 (0.68, 1.42) 0.92
Radiotherapy 0.92 (0.71, 1.20) 0.55 (1.57 (1.09, 2.27) 0.016
Karnofsky Performance  
Status Score
80
90 0.77 (0.51, 1.15) 0.55 (0.32, 0.92)
100 0.63 (0.43, 0.93) 0.44 (0.26, 0.77)
0.10 0.017
Initial Surgery
GTR 0.69 (0.49, 0.96) 0.82 (0.53, 1.28)
Biopsy only 1.13 (0.78, 1.64) 1.35 (0.82, 2.24)
0.03 0.17
Location
Temporal
Frontal 1.00 (0.72, 1.40) 0.78 (0.49, 1.26)
Parietal 1.26 (0.78, 2.05) 1.23 (0.72, 2.50)
Other 0.87 (0.31, 2.46) 1.43 (0.42, 4.93)
0.66 0.16

GTR: gross total resection; STR: subtotal resection.