Table 2.

Bivariate (unadjusted) analyses for survival

	Progression-free Survival		Overall Survival
Covariate	Hazard Ratio (95% CI)	Chi-square P-value	Hazard Ratio (95% CI)	Chi-square P-value
1p/19q status
1p/19q loss without polysomy	–	–	–	–
1p/19q loss with polysomy (all)	2.08 (1.52, 2.84)	<0.0001	1.52 (0.97, 2.38)	0.07
1p/19q maintenance (all)	3.66 (2.47, 5.42)	<0.0001	4.26 (2.63, 6.90)	<0.0001
		<0.0001		<0.0001
Age	1.02 (1.01, 1.03)	0.0003	1.04 (1.02, 1.05)	<0.0001
Sex
Female	–	–	–	–
Male	1.11 (0.85, 1.45)	0.43	1.10 (0.77, 1.58)	0.60
Pathology diagnosis	1.08 (0.72, 1.61)	0.73	1.15 (1.95, 0.68)	0.60
WHO grade III	2.09 (1.58, 2.78)	<0.0001	2.57 (1.70, 3.87)	<0.0001
Ki67	1.01 (0.995, 1.02)	0.31	1.01 (0.995, 1.02)	0.20
IDH1/2 mutation	0.76 (0.46, 1.27)	0.30	0.57 (0.24, 1.34)	0.20
Chemotherapy	1.12 (0.85, 1.47)	0.41	0.98 (0.68, 1.42)	0.92
Radiotherapy	0.92 (0.71, 1.20)	0.55	(1.57 (1.09, 2.27)	0.016
Karnofsky Performance   Status Score
80	–	–	–	–
90	0.77 (0.51, 1.15)		0.55 (0.32, 0.92)
100	0.63 (0.43, 0.93)		0.44 (0.26, 0.77)
		0.10		0.017
Initial Surgery
GTR	0.69 (0.49, 0.96)		0.82 (0.53, 1.28)
Biopsy only	1.13 (0.78, 1.64)		1.35 (0.82, 2.24)
		0.03		0.17
Location
Temporal	–	–	–	–
Frontal	1.00 (0.72, 1.40)		0.78 (0.49, 1.26)
Parietal	1.26 (0.78, 2.05)		1.23 (0.72, 2.50)
Other	0.87 (0.31, 2.46)		1.43 (0.42, 4.93)
		0.66		0.16

GTR: gross total resection; STR: subtotal resection.