Table 3.

Multivariate analysis for survival

Covariate	Hazard Ratio (95% CI)	Wald Chi-Square P-Value
Hazard ratios for PFS
1p/19q status
1p/19q loss without polysomy	-
1p/19q loss with polysomy	1.96 (1.42, 2.71)
1p/19q maintenance	3.64 (2.470, 5.46)
		<0.0001
Age	1.02 (1.01, 1.03)	0.001
WHO grade III	2.88 (1.43, 2.57)	<0.0001
Initial Surgery
Subtotal resection	–
Gross total resection	0.64 (0.49, 0.91)
Biopsy only	1.21 (0.80, 1.70)
		0.007
Hazard ratios for OS
1p/19q status
1p/19q loss without polysomy	–
1p/19q loss with polysomy	1.35 (0.84, 2.15)
1p/19q maintenance	4.52 (2.70, 7.55)
		<0.0001
Age	1.04 (1.02, 1.05)	<0.0001
WHO grade III	2.24 (1.43, 3.51)	0.0004
Radiotherapy at initial diagnosis	0.94 (0.62, 1.41)	0.81
KPS
80	–
90	0.56 (0.37, 1.10)
100	0.64 (0.28, 1.07)
		0.36