Skip to main content
. 2020 Apr 29;5:100077. doi: 10.1016/j.bbih.2020.100077

Fig. 7.

Fig. 7

Chemokines are differentially altered by HIV-1 Tat in distinct regions of the frontal cortico-BG-thalamocortical circuit. Chemotactic cytokine protein expression in Tat(+) mice (color bars) was inversely changed in discrete regions of the frontal cortico-BG-thalamocortical circuit after 48 ​h, 2 weeks, or 8 weeks of DOX. CCL4 (C), CXCL1 (F), and G-CSF (G) levels were increased in the PFC after 48 ​h to 8 weeks of Tat exposure. Regardless of exposure time, Tat increased CCL5 (D) expression in the striatum; whereas in the thalamus expression was decreased. CCL11 (E) levels were also increased in the striatum after 48 ​h to 8 weeks of Tat (D). Data are presented as mean ​± ​SEM; n ​= ​6–9 mice per group. Main effect, ∗p ​< ​0.05 vs respective Tat(−) (control) (white bars) within discrete regions. Main effect of exposure time within each separate region, #p ​< ​0.05 vs respective 48 ​h exposure time; ‡p ​< 0.05 vs respective 2-week exposure time.