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. 2020 Apr 29;5:100077. doi: 10.1016/j.bbih.2020.100077

Fig. 9.

Fig. 9

HIV-1 Tat-dependent alterations in CCL4, CXCL1, IL-12p40, and IL-17A levels in the PFC interact to predict mobility in the forced swim test (FST). Multiple linear regression interaction plots demonstrate that Tat and IL-12p40 (A) or CXCL1 (B) expression in the PFC significantly interacted to predict an increase in FST mobility irrespective of Tat exposure time. Interaction plots of Tat, exposure duration, and IL-17A (C) or CCL4 (D) expression indicate that Tat-dependent increases in either cytokine in the PFC at 2 weeks following Tat exposure predict an increase in mobility, whereas at 8 weeks of exposure predict a decrease in mobility. Other Tat-dependent alterations in cytokine levels in the PFC did not significantly predict behavioral outcomes. Data are presented as mean ​± ​SEM; n ​= ​6–9 mice per group.