Table 1.

Effects of brain region, Tat, and the duration of DOX exposure on chemokine levels.

Brain Region		Main Effect of Tat		Tat/DOX Duration		Interaction
PFC	Chemokine	F(1,34)	p	F(2,34)	p	F(2,34)	p
	CCL2	2.96	0.95	14.35	<0.01#	2.95	0.07
	CCL3	0.01	0.91	16.24	<0.01#	3.41	0.04
	CCL4	6.48	0.02	29.46	<0.01#	1.20	0.32
	CCL5	0.78	0.38	213.80	<0.01#	0.54	0.59
	CCL11	1.36	0.25	101.90	<0.01#	0.12	0.89
	CXCL1	6.06	0.02	1.49	0.24	1.72	0.19
	G-CSF	5.03	0.03	2.00	0.15	1.27	0.29
	GM-CSF	0.72	0.40	13.47	<0.01#	0.38	0.69
Striatum	Chemokine	F(1,32)	p	F(2,32)	p	F(2,32)	p
	CCL2	0.06	0.80	13.12	<0.01#	2.09	0.14
	CCL3	0.12	0.73	3.98	0.03‡	2.51	0.10
	CCL4	1.76	0.19	0.22	0.80	2.25	0.12
	CCL5	4.17	0.05	0.32	0.73	0.62	0.55
	CCL11	5.94	0.02	8.96	<0.01#	0.85	0.44
	CXCL1	0.51	0.48	2.56	0.09	1.90	0.17
	G-CSF	0.22	0.64	18.52	<0.01@‡	0.27	0.77
	GM-CSF	1.20	0.28	1.55	0.23	1.77	0.19
Thalamus	Chemokine	F(1,31)	p	F(2,31)	p	F(2,31)	p
	CCL2	0.17	0.68	35.20	<0.01#‡	0.37	0.70
	CCL3	0.00	0.98	0.84	0.44	0.45	0.64
	CCL4	0.56	0.46	1.95	0.16	0.50	0.61
	CCL5	5.25	0.03	191.00	<0.01$	1.64	0.21
	CCL11	0.57	0.46	985.20	<0.01+‡	3.16	0.06
	CXCL1	0.23	0.64	21.45	<0.01#	0.24	0.79
	G-CSF	0.46	0.50	26.13	<0.01$	0.18	0.83
	GM-CSF	0.13	0.72	33.76	<0.01$	0.05	0.95

The F-values, degrees of freedom, and P-values from the chemokine ANOVA results. Bolded values denote significant differences at α ​= ​0.05 (Bonferroni correction for multiple comparisons). Main effect of exposure time within each separate region, ^$ All exposure time-points (48 ​h, 2-week, and 8-week) are significantly different, ^# 48 ​h exposure time-point significantly differs from respective 2- and 8-week DOX exposure time-points; ^@ 48 ​h exposure time-point differs from the respective 2-week exposure time-point; ⁺ 48 ​h exposure time-point differs from its respective 8-week exposure time-point; ^‡ 2-week exposure time-point differs from the respective 8-week exposure time-point.