Table 3.
Effects of brain region, Tat, and the duration of DOX exposure on anti-inflammatory cytokine levels.
| Brain Region | Main Effect of Tat | Tat/DOX Duration | Interaction | ||||
|---|---|---|---|---|---|---|---|
| PFC | Cytokine | F(1,34) | p | F(2,34) | p | F(2,34) | p |
| IL-4 | 9.88 | <0.01 | 28.82 | <0.01# | 1.77 | 0.19 | |
| IL-5 | 0.10 | 0.32 | 1.98 | 0.15 | 0.25 | 0.78 | |
| IL-10 | 8.17 | <0.01 | 4.67 | <0.01# | 1.41 | 0.26 | |
| IL-13 | 0.84 | 0.37 | 47.64 | <0.01$ | 0.23 | 0.80 | |
| Striatum | Cytokine | F(1,32) | p | F(2,32) | p | F(2,32) | p |
| IL-4 | 3.10 | 0.09 | 19.61 | <0.01$ | 2.32 | 0.11 | |
| IL-5 | 0.41 | 0.52 | 3.23 | 0.05 | 3.16 | 0.06 | |
| IL-10 | 0.02 | 0.88 | 20.19 | <0.01# | 1.97 | 0.16 | |
| IL-13 | 0.40 | 0.53 | 9.68 | <0.01@‡ | 0.61 | 0.55 | |
| Thalamus | Cytokine | F(1,31) | p | F(2,31) | p | F(2,31) | p |
| IL-4 | 0.58 | 0.45 | 2.22 | 0.13 | 0.69 | 0.51 | |
| IL-5 | 0.11 | 0.75 | 4.60 | 0.02@‡ | 0.00 | 0.99 | |
| IL-10 | 0.05 | 0.83 | 199.40 | <0.01$ | 0.05 | 0.95 | |
| IL-13 | 4.50 | 0.04 | 17.90 | <0.01@‡ | 0.81 | 0.45 | |
The F-values, degrees of freedom, and P-values from the anti-inflammatory cytokine ANOVA results. Bolded values denote significant differences at α = 0.05 (Bonferroni correction for multiple comparisons). Main effect of exposure time within each separate region, $ All exposure time-points (48 h, 2-week, and 8-week) are significantly different, # 48 h exposure time-point significantly differs from its respective 2- and 8-week DOX exposure time-points; @ 48 h exposure time-point differs from its respective 2-week exposure time-point; + 48 h exposure time-point differs from its respective 8-week exposure time-point; ‡ 2-week exposure time-point differs from its respective 8-week exposure time-point.