Table 4. Three-biomarker models.
Benign tumors vs. cancer.
| Reference model | AUC (95%) | Rank | p-valuea | Sensitivity at 95% specificity | Specificity at 95% sensitivity |
|---|---|---|---|---|---|
| HE4+CA125+age | 0.838 (0.752–0.924) | - | - | 0.483 (0.207–0.759) | 0.350 (0.111–0.709) |
| Additional marker | |||||
| CXCL1 | 0.874 (0.803–0.945) | 1 | 0.068 | 0.448 (0.207–0.655) | 0.581 (0.137–0.803) |
| ITGAV | 0.874 (0.799–0.949) | 2 | 0.045 | 0.621 (0.207–0.862) | 0.530 (0.188–0.709) |
| CXCL6 | 0.872 (0.803–0.942) | 3 | 0.150 | 0.448 (0.138–0.724) | 0.444 (0.325–0.821) |
| SCAMP3 | 0.869 (0.797–0.942) | 4 | 0.094 | 0.379 (0.172–0.724) | 0.462 (0.239–0.787) |
| ABL1 | 0.868 (0.794–0.942) | 5 | 0.111 | 0.414 (0.172–0.724) | 0.385 (0.265–0.786) |
| VEGFR-2 | 0.863 (0.777–0.948) | 6 | 0.304 | 0.586 (0.172–0.793) | 0.291 (0.145–0.701) |
| CD40 | 0.859 (0.784–0.935) | 7 | 0.154 | 0.414 (0.138–0.724) | 0.444 (0.231–0.769) |
| CXCL11 | 0.859 (0.780–0.937) | 8 | 0.197 | 0.414 (0.207–0.690) | 0.316 (0.197–0.744) |
| DNER | 0.858 (0.775–0.941) | 9 | 0.157 | 0.586 (0.310–0.793) | 0.564 (0.026–0.684) |
| SCF | 0.858 (0.774–0.942) | 10 | 0.246 | 0.517 (0.276–0.724) | 0.342 (0.060–0.744) |
| TNFSF14 | 0.851 (0.770–0.931) | 11 | 0.304 | 0.379 (0.172–0.724) | 0.299 (0.188–0.744) |
| CTSV | 0.849 (0.764–0.934) | 12 | 0.526 | 0.552 (0.241–0.759) | 0.333 (0.137–0.752) |
| CXCL13 | 0.848 (0.771–0.925) | 13 | 0.363 | 0.414 (0.103–0.690) | 0.496 (0.197–0.709) |
| FR-alpha | 0.846 (0.769–0.924) | 14 | 0.471 | 0.483 (0.138–0.759) | 0.444 (0.274–0.684) |
| MMP-1 | 0.846 (0.762–0.930) | 15 | 0.318 | 0.517 (0.138–0.725) | 0.359 (0.085–0.744) |
| IL10 | 0.842 (0.758–0.926) | 16 | 0.543 | 0.448 (0.069–0.725) | 0.350 (0.103–0.735) |
| TNFB | 0.842 (0.754–0.930) | 17 | 0.715 | 0.483 (0.241–0.759) | 0.316 (0.085–0.701) |
| CSF-1 | 0.841 (0.756–0.925) | 18 | 0.409 | 0.483 (0.207–0.724) | 0.393 (0.137–0.692) |
| CXCL9 | 0.840 (0.756–0.925) | 19 | 0.759 | 0.483 (0.172–0.759) | 0.316 (0.197–0.692) |
| IL-10RB | 0.840 (0.760–0.920) | 20 | 0.779 | 0.448 (0.103–0.690) | 0.504 (0.154–0.684) |
| PVRL4 | 0.839 (0.754–0.925) | 21 | 0.846 | 0.517 (0.207–0.759) | 0.402 (0.171–0.692) |
| TNFRSF6B | 0.839 (0.753–0.925) | 22 | 0.143 | 0.483 (0.207–0.759) | 0.350 (0.111–0.709) |
| WISP-1 | 0.839 (0.753–0.925) | 23 | 0.775 | 0.448 (0.207–0.724) | 0.359 (0.085–0.701) |
| CCL3 | 0.838 (0.752–0.925) | 24 | 0.565 | 0.517 (0.207–0.759) | 0.355 (0.103–0.684) |
| CDCP1 | 0.838 (0.753–0.924) | 25 | 0.893 | 0.483 (0.172–0.759) | 0.368 (0.103–0.701) |
| TNFRSF4 | 0.838 (0.755–0.921) | 26 | 0.962 | 0.483 (0.207–0.724) | 0.410 (0.137–0.692) |
| CCL23 | 0.838 (0.750–0.925) | 27 | 1.000 | 0.448 (0.172–0.724) | 0.376 (0.077–0.701) |
| MK | 0.837 (0.751–0.924) | 28 | 0.930 | 0.448 (0.138–0.724) | 0.308 (0.120–0.692) |
| RSPO3 | 0.837 (0.752–0.923) | 29 | 0.900 | 0.448 (0.172–0.724) | 0.333 (0.094–0.701) |
| VEGFA | 0.837 (0.749–0.925) | 30 | 0.836 | 0.414 (0.138–0.724) | 0.299 (0.068–0.718) |
| TFPI-2 | 0.836 (0.749–0.924) | 31 | 0.737 | 0.483 (0.207–0.724) | 0.342 (0.060–0.692) |
| IL6 | 0.834 (0.743–0.926) | 32 | 0.647 | 0.483 (0.172–0.759) | 0.282 (0.026–0.684) |
a Comparing the reference model and the reference model with an added biomarker.