Table 8. Three-biomarker models.
Benign tumors vs. borderline + cancer.
| Reference model | AUC (95%) | Rank | p-valuea | Sensitivity at 95% specificity | Specificity at 95% sensitivity |
|---|---|---|---|---|---|
| HE4+CA-125+age | 0.770 (0.674–0.865) | - | - | 0.172 (0.035–0.483) | 0.196 (0.105–0.629) |
| Additional marker | |||||
| ITGAV | 0.818 (0.737–0.900) | 1 | 0.047 | 0.276 (0.103–0.517) | 0.441 (0.168–0.650) |
| VEGFR-2 | 0.816 (0.725–0.908) | 2 | 0.132 | 0.345 (0.103–0.586) | 0.252 (0.091–0.664) |
| DNER | 0.808 (0.720–0.896) | 3 | 0.075 | 0.241 (0.034–0.552) | 0.476 (0.028–0.615) |
| CTSV | 0.803 (0.710–0.897) | 4 | 0.206 | 0.379 (0.207–0.586) | 0.301 (0.105–0.587) |
| SCF | 0.794 (0.702–0.885) | 5 | 0.204 | 0.207 (0.034–0.483) | 0.245 (0.063–0.643) |
| CXCL13 | 0.792 (0.708–0.875) | 6 | 0.240 | 0.310 (0.138–0.517) | 0.448 (0.231–0.601) |
| MMP-1 | 0.785 (0.694–0.876) | 7 | 0.198 | 0.241 (0.069–0.484) | 0.245 (0.077–0.671) |
| FR-alpha | 0.777 (0.690–0.864) | 8 | 0.533 | 0.172 (0.034–0.517) | 0.343 (0.245–0.587) |
| IL10 | 0.774 (0.681–0.867) | 9 | 0.364 | 0.172 (0.034–0.448) | 0.217 (0.084–0.622) |
| IL6 | 0.774 (0.675–0.874) | 10 | 0.628 | 0.276 (0.034–0.552) | 0.119 (0.035–0.608) |
| WISP-1 | 0.772 (0.679–0.866) | 11 | 0.661 | 0.207 (0.034–0.449) | 0.252 (0.084–0.643) |
| MK | 0.772 (0.677–0.867) | 12 | 0.609 | 0.207 (0.034–0.517) | 0.203 (0.112–0.615) |
| TNFRSF6B | 0.772 (0.676–0.867) | 13 | 0.672 | 0.207 (0.034–0.517) | 0.238 (0.056–0.601) |
a Comparing the reference model and the reference model with an added biomarker.