TABLE 1.

Clinical Notes for the Isolated Severe fTBI vs. t-Control Patients

Cohort	Clinical Synopsis	Autopsy Cause of Death
fTBI	A 20-year-old man with isolated GSW to head who presented in PEA arrest, but regained pulses with resuscitation and underwent decompressive craniectomy—declared brain dead	GSW head Brain dead
fTBI	An 18-year-old man with multiple GSWs to head complicated by intracranial midline shift, herniation, and loss of brainstem reflexes—declared brain dead	GSW head Brain dead
fTBI	An 18-year-old man who was bluntly assaulted to head found to have diffuse SAH—declared brain dead	BFI to head Brain dead
fTBI	A 53-year-old man who was found down with head trauma who underwent decompressive hemicraniectomy for a large SDH—declared brain dead	BFI to head Brain dead
fTBI	A 36-year-old man who was found down with head trauma and without a pulse and received resuscitation with return of circulation. He was found to have a large SDH with uncal herniation—declared brain dead	BFI to head Brain dead
fTBI	A 65-year-old man who fell down 12 stairs with a large SDH and parenchymal contusions—declared brain dead	BFI to head Brain dead
fTBI	A 28-year-old woman with isolated GSW to head complicated by SDH, diffuse SAH, and uncal herniation—declared brain dead	GSW head Brain dead
fTBI	A 20-year-old man with isolated GSW to the head found to have SDH and intraparenchymal hemorrhage—declared brain dead	GSW head Brain dead
fTBI	A 30-year-old man with isolated GSW to head who presented in PEA arrest, but regained pulses with resuscitation, found to have large SDH, IVH, and loss of brainstem reflexes—declared brain dead	GSW head Brain dead
fTBI	A 23-year-old man with isolated GSW to head with significant blood loss and associated shock who underwent decompressive hemicraniectomy—declared brain dead	GSW head Brain dead
t-control	A 34-year-old man who was in a motor vehicle collision—no injuries identified	n/a
t-control	A 50-year-old found down with occipital hematoma—no injuries identified	n/a
t-control	A 21-year-old man with GSWs to left and right thigh—minor soft tissue injuries only	n/a
t-control	A 24-year-old man with stab wound to the left wrist—minor soft tissue injuries only	n/a
t-control	A 30-year-old man who was in a motor vehicle collision—no injuries identified	n/a

Cause of death determined by autopsy.

GSW, gunshot wound; BFI, blunt force injury; SDH, subdural hematoma; SAH, subarachnoid hemorrhage; IVH, intraventricular hemorrhage; GCS, Glasgow Coma Scale; ICU, intensive care unit; PEA, pulseless electrical activity.