Table 1.
Univariate and multivariate Cox regression analyses were performed on the gene signatures and RFS of BC patients
| Variables | Patients(N) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| HR(95% CI) | P | HR(95% CI) | P | |||
| GSE42568 | ||||||
| T_stage | I/II&III | 18/83 | 1.29(0.57‐2.89) | 0.538 | 0.94(0.37‐1.96) | 0.69 |
| ER | ∓ | 34/67 | 0.44(0.24‐0.79) | 6.35e‐03 | 0.38(0.20‐0.74) | 4.19e‐03 |
| Nodes | ∓ | 44/57 | 4.55(2.19‐9.48) | 5.20e‐05 | 4.82(2.23‐10.39) | 6.11e‐05 |
| Grade | I&II/III | 50/51 | 2.82(1.51‐5.29) | 1.18e‐03 | 1.05(0.50‐2.18) | 0.90 |
| Risk score | Low/High | 50/51 | 4.02(2.07‐7.83) | 4.14e‐05 | 3.60(1.72‐7.52) | 6.54e‐04 |
| Total（GSE42568&GSE20711&GSE21653） | ||||||
| T_stage | I/II | 119/239 | 1.18(0.82‐1.71) | 0.38 | 1.08(0.74‐1.59) | 0.68 |
| T_stage | I/III | 119/65 | 2.29(1.39‐3.76) | 1.06e‐03 | 1.86(1.12‐3.11) | 1.58e‐03 |
| ER | ∓ | 179/244 | 0.61(0.45‐0.84) | 2.41e‐03 | 0.67(0.47‐0.94) | 2.14e‐03 |
| Nodes | ∓ | 186/237 | 2.14(1.51‐3.02) | 1.68e‐05 | 1.84(1.29‐2.64) | 8.22e‐04 |
| Grade | I/II | 66/126 | 1.86(1.00‐3.47) | 4.99e‐03 | 1.73(0.91‐3.26) | 0.09 |
| Grade | I/III | 66/231 | 2.59(1.45‐4.62) | 1.27e‐03 | 1.73(0.94‐3.20) | 0.08 |
| Risk score | Low/High | 210/213 | 2.53(1.80‐3.56) | 8.49e‐08 | 2.32(1.64‐3.29) | 1.87e‐06 |