TABLE 2.

Univariate and multivariate Cox regression analyses of clinicopathologic characteristics associated with overall survival in The Cancer Genome Atlas samples

Variable	The training set				The testing set				The entire set
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	P‐value	HR (95% CI)	P‐value	HR (95% CI)	P‐value	HR (95% CI)	P‐value	HR (95% CI)	P‐value	HR (95% CI)	P‐value
Age (>60/≤60)	0.999 (0.967‐1.032)	.954	—	—	1.039 (1.004‐1.076)	.027	1.057 (1.014‐1.102)	.009 a	1.018 (0.995‐1.041)	.125	—	—
Gender (male/female)	0.445 (0.203‐0.976)	.043 a	0.557 (0.222‐1.394)	.211	0.883 (0.393‐1.982)	.762	—	—	0.601 (0.345‐1.048)	.073	—	—
Grade (G4/G3/G2/G1)	1.885 (1.168‐2.584)	.009 a	2.76 (1.423‐5.368)	.003 a	0.967 (0.529‐1.768)	.914	—	—	1.458 (0.997‐2.133)	.052	—	—
Stage (IV/III/II/I)	1.733 (1.162‐2.584)	.007 a	2.945 (1.112‐7.776)	.029 a	1.445 (0.866‐2.411)	.158	—	—	1.595 (1.184‐2.148)	.002 a	2.479 (0.953‐6.450)	.063
T stage (T4/T3/T2/T1)	1.56 (1.051‐2.316)	.028 a	0.691 (0.275‐1.733)	.431	1.506 (0.923‐2.458)	.102	—	—	1.524 (1.134‐2.047)	.005 a	0.647 (0.250‐1.673)	.369
Albumin (>3.5/≤3.5 g/dL)	0.999 (0.983‐1.015)	.9	—	—	0.825 (0.598‐1.138)	.241	—	—	0.964 (0.740‐1.255)	.784	—	—
Platelet (>250/≤250 × 109/L)	0.999 (0.998‐1.000)	.625	—	—	1.000 (0.999‐1.001)	.941	—	—	0.999 (0.998‐1.001)	.288	—	—
AFP (>20/≤20 ng/mL)	1 (0.999‐1.002)	.329	—	—	0.998 (0.993‐1.003)	.584	—	—	0.999 (0.997‐1.001)	.435	—	—
Vascular invasion (macro/micro/none)	1.693 (0.897‐3.190)	.103	—	—	2.080 (1.190‐3.634)	.01 a	3.768 (1.778‐7.984)	<.001 a	1.920 (1.263‐2.920)	.002 a	1.962 (1.223‐3.144)	.005 a
Risk score	1.632 (1.284‐2.075)	<.001 a	1.507 (1.134‐2.002)	.005 a	1.180 (1.019‐1.366)	.03 a	1.289 (1.046‐1.590)	.017 a	1.257 (1.125‐1.406)	<.001 a	1.201 (1.054‐1.370)	.006 a

Abbreviations: AFP, alpha‐fetoprotein; CI, confidence interval; HR, hazard ratio.

^aStatistically significant.