Table 4. Immunoglobulin G1, G2 and M values at baseline and follow-up.

	Placebo Group (n = 62)							Bio-Germanium Group (n = 66)
(mg/dL)	Baseline				Follow-up			Baseline				Follow-up			Pa	Pb	Pc
IgG1	82804.84	±	15720.12		80725.81	±	14306.39**	79272.73	±	15087.10		78996.97	±	16327.15	0.197	0.396
Δ			-2079.03	±	5006.03					-275.76	±	4996.28					0.044
IgG2	47364.52	±	18764.35		45503.89	±	18729.89**	43692.42	±	18349.00		43325.76	±	17725.25	0.269	0.412
Δ			-1860.63	±	5286.78					-366.67	±	2953.09					0.076
IgM	114.76	±	63.12		114.63	±	63.27	109.68	±	62.41		112.15	±	62.81*	0.691	0.858
Δ			-0.13	±	9.44					2.47	±	7.83					0.092

The data represent the mean ± standard deviation.

Δ represents the change from baseline at follow-up.

P^a-values were derived from an independent t-test (IgG1, normally distributed) or the Wilcoxon rank-sum test (IgG2 and IgM, not normally distributed) at baseline between groups.

P^b-values were derived from the Wilcoxon rank-sum test at follow-up between groups.

P^c-values were derived from an independent t-test (IgG1 and IgM, normally distributed) or the Wilcoxon rank-sum test (IgG2, not normally distributed) for Δ between groups.

*P<0.05 and **P<0.01 values were derived from a paired t-test at follow-up from baseline within groups.