Table 2: Profile of fasting and post-mixed meal extended lipid profile parameters across the spectrum of thyroid dysfunction.
| Parameter | Overt primary hypothyroidism (n=33) | Subclinical hypothyroidism (n=161) | Euthyroid controls (n=40) | p value |
|---|---|---|---|---|
| TC, mg/dL* | 180.01 (144.02–201.01) | 165.00 (151.03–184.51) | 154.50 (141.10–177.74) | 0.051 |
| 1h PM TC, mg/dL* | 172.00 (139.52–198.10) | 161.07 (146.03–180.10) | 152.04 (139.75–171.51) | 0.037 |
| 2h PM TC, mg/dL* | 165.10 (138.03–196.02) | 159.03 (145.10–176.11) | 150.11 (138.52–168.75) | 0.043 |
| 4h PM TC, mg/dL* | 175.04 (143.02–196.10) | 163.02 (149.10–181.04) | 149.07 (140.21–168.81) | 0.023 |
| LDL-C, mg/dL* | 109.12 (87.04–144.03) | 98.01 (83.09–113.08) | 92.06 (77.08–108.22) | 0.009 |
| 1h PM LDL-C, mg/dL* | 104.11 (80.51–128.12) | 91.08 (76.10–103.09) | 86.13 (66.72–92.75) | 0.009 |
| 2h PM LDL-C, mg/dL* | 98.11 (83.50–119.12) | 84.14 (69.52–99.51) | 79.51 (66.02–92.74) | 0.004 |
| 4h PM LDL-C, mg/dL* | 92.04 (73.11–113.03) | 78.11 (67.03–96.51) | 75.53 (62.10–91.53) | 0.005 |
| HDL-C, mg/dL | 43.54 ± .61 | 44.59 ± 82 | 42.53 ± 12.01 | 0.641 |
| 1h PM HDL-C, mg/dL | 42.52 ± 9.33 | 43.22 ± 9.04 | 42.51 ± 12.01 | 0.878 |
| 2h PM HDL-C, mg/dL | 41.36 ± 9.18 | 42.49 ± 8.36 | 41.51 ± 12.26 | 0.736 |
| 4h PM HDL-C, mg/dL | 42.03 ± 9.33 | 42.88 ± 9.50 | 41.25 ± 12.93 | 0.635 |
| TG, mg/dL* | 118.10 (83.03–176.52) | 126.07 (82.51–168.03) | 104.52 (81.11–161.51) | 0.671 |
| 1h PM TG, mg/dL* | 128.21 (107.10–180.52) | 133.11 (91.08–179.02) | 117.21 (97.03–176.04) | 0.932 |
| 2h PM TG, mg/dL* | 151.11 (112.08–202.05) | 164.80 (113.51–212.53) | 135.51 (106.21–193.75) | 0.651 |
| 4h PM TG, mg/dL* | 171.03 (136.01–233.17) | 182.52 (136.50–259.53) | 161.00 (116.03–263.25) | 0.624 |
| Lp-a, mg/dL* | 13.12 (6.28–22.00) | 10.12 (5.26–21.47) | 6.82 (4.26–12.35) | 0.027 |
| 1h PM Lp-a, mg/dL* | 12.50 (6.20–21.41) | 10.01 (5.02–21.13) | 6.81 (4.28–12.30) | 0.019 |
| 2h PM Lp-a, mg/dL* | 11.95 (6.38–20.72) | 10.16 (5.02–20.68) | 6.77 (4.36–12.00) | 0.022 |
| 4h PM Lp-a, mg/dL* | 11.82 (6.72–20.72) | 9.12 (4.80–20.47) | 6.91 (4.40–11.71) | 0.033 |
| Apo-A1, mg/dL* | 131.23 (115.78–155.70) | 144.47 (127.72–164.59) | 142.25 (125.73–151.72) | 0.246 |
| 1h PM apo-A1, mg/dL* | 129.57 (109.34–157.02) | 139.53 (123.30–159.10) | 135.53 (122.57–146.78) | 0.232 |
| 2h PM apo-A1, mg/dL* | 124.20 (107.81–143.90) | 136.23 (121.23–156.42) | 136.35 (125.20–148.90) | 0.032 |
| 4h PM apo-A1, mg/dL* | 122.93 (109.39–148.41) | 137.56 (121.01–157.38) | 134.53 (122.59–149.88) | 0.034 |
| Apo-B, mg/dL | 99.71 (90.52–130.59) | 107.32 (90.00–120.80) | 100.27 (85.32–117.58) | 0.282 |
| 1h PM apo-B, mg/dL | 97.56 (89.20–136.50) | 105.84 (89.94–118.28) | 97.21 (85.21–112.67) | 0.133 |
| 2h PM apo-B, mg/dL | 97.72 (88.46–123.47) | 105.01 (88.19–119.70) | 97.76 (81.55–111.05) | 0.672 |
| 4h PM apo-B, mg/dL | 98.03 (88.95–119.83) | 105.48 (89.76–118.95) | 97.22 (84.22–109.08) | 0.394 |
p<0.05 considered statistically significant (in bold); p-values have been calculated between the three groups using analysis of variance (ANOVA). All normally distributed continuous variables expressed as mean ± standard deviation. *all non-normally distributed variables expressed as median (25th–75th percentile).
apo-A1 = apolipoprotein-A1; apo-B = apolipoprotein-B; h = hour; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; HDL-C = high-density
lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol; Lp-a = lipoprotein-a; PM = post meal; TC = total cholesterol; TG = triglycerides.