Table 1: Comparison of demographic, anthropometric and clinical parameters between euthyroid patients with PCOS and those with subclinical hypothyroidism and PCOS.
Variables | All subjects (n=465) | Euthyroid (n=415) | SCH (n=50) | p value |
---|---|---|---|---|
Age, mean years ± SD | 22.52 ± 5.38 | 22.37 ± 5.38 | 23.76 ± 5.27 | 0.085 |
Age at onset of PCOS symptoms, mean years ± SD | 17.79 ± 5.20 | 17.64 ± 5.09 | 19.04 ± 5.91 | 0.073 |
Married, % | 47.7 | 46.7 | 56.0 | 0.233 |
Menstrual irregularity, % | 92.9 | 92.8 | 94.0 | 1.000 |
Hirsutism, % | 74.4 | 76.4 | 58.0 | 0.009 |
Modified FG score, mean ± SD | 11 ± 6 | 11 ± 6 | 9 ± 5 | 0.003 |
Acne, % | 18.9 | 19.0 | 18.0 | 1.000 |
Gained weight*, % | 58.5 | 56.9 | 72.0 | 0.048 |
Subfertility,† (in married patients, n=221), % | 36.7 | 36.3 | 39.3 | 0.834 |
Family history of thyroid disease, % | 2.8 | 2.7 | 4.0 | 0.640 |
BMI, mean kg/m2 ± SD | 26.63 ± 5.12 | 26.53 ± 5.14 | 27.39 ± 4.93 | 0.264 |
Overweight/obese, % | 76.8 | 75.2 | 90.0 | 0.020 |
WC, mean cm ± SD | 87.57 ± 11.70 | 87.34 ± 11.87 | 89.54 ± 10.09 | 0.209 |
Central obesity, % | 75.3 | 73.7 | 88.0 | 0.025 |
Acanthosis nigricans, % | 80.9 | 80.2 | 86.0 | 0.446 |
Goiter, % | 56.1 | 53.3 | 80.0 | <0.001 |
Systolic BP, mean mmHg ± SD | 115 ± 12 | 112 ± 12 | 118 ± 13 | 0.098 |
Diastolic BP, mean mmHg ± SD | 75 ± 8 | 75 ± 9 | 75 ± 8 | 0.553 |
Pre-HTN/HTN, % | 24.7 | 23.9 | 32.0 | 0.225 |
p value by Student’s t-test or Chi-square test as applicable.
*In the 6 months prior to PCOS diagnosis.
†Failure to conceive after 1 year of unprotected regular (2 x week) sexual intercourse; the male partner was fertile evidenced by a normal semen analysis report.
BMI = body mass index; BP = blood pressure; FG = Ferriman–Gallwey;
HTN = hypertension; PCOS = polycystic ovary syndrome; SCH = subclinical hypothyroidism; SD = standard deviation; WC = waist circumference.