Table 2: Comparison of metabolic and hormonal parameters between the euthyroid and subclinical hypothyroidism study populations.

Variables	All subjects (n=465)	Euthyroid (n=415)	SCH (n=50)	p value
FPG, mean mmol/L ± SD	5.08 ± 1.20	5.09 ± 1.24	4.97 ± 0.81	0.492
PG 2H-OGTT, mean mmol/L ± SD	6.91 ± 2.43	6.93 ± 2.50	6.71 ± 1.70	0.553
Prediabetes/diabetes, %	24.3	24.1	26.0	0.730
TC, mean mg/dL ± SD	172.07 ± 33.88	171.89 ± 34.21	173.54 ± 31.33	0.745
TG, mean mg/dL ± SD	144.20 ± 54.18	143.12 ± 53.92	153.14 ± 56.09	0.217
LDL-C, mean mg/dL ± SD	103.88 ± 27.62	104.06 ± 27.49	102.32 ± 28.95	0.673
HDL-C, mean mg/dL ± SD	38.39 ± 6.96	38.38 ± 7.01	38.57 ± 6.59	0.853
Dyslipidaemia, %	87.5	87.5	88.0	1.000
Metabolic syndrome, %	44.5	43.1	56.0	0.098
Serum testosterone, median ng/mL (IQR)	0.72 (0.43–1.11)	0.73 (0.44–1.12)	0.55 (0.29–0.98)	0.194
Serum prolactin, median ng/mL (IQR)	12.36 (8.65–21.55)	12.25 (8.75–20.98)	13.61 (7.57–26.70)	0.642
Elevated testosterone, %	19.4	19.8	16.0	0.704
Elevated prolactin, %	13.1	12.8	16.0	0.508
Serum TSH, median μIU/mL (IQL)	1.44 (0.88–2.79)	1.32 (0.83–2.15)	7.38 (5.74–9.81)	<0.001
Serum FT4, mean ng/dL ± SD	1.29 ± 0.30	1.31 ± 0.29	1.09 ± 0.29	<0.001
Serum anti-TPO, median IU/mL (IQR)	9.71 (3.25–25.73)	7.76 (3.08–15.64)	88.02 (10.00–560.29)	<0.001
Anti-TPO positive, %	18.3	13.0	62.0	<0.001

p value by Student’s t-test, Chi-square test or Mann–Whitney U test as applicable.

Anti-TPO = anti-thyroid peroxidase; FPG = fasting plasma glucose; FT4 = free thyroxine; HDL-C = high-density lipoprotein cholesterol; IQR = interquartile range;

LDL-C = low-density lipoprotein cholesterol; PG 2H-OGTT = plasma glucose 2 hours after oral glucose tolerance test; SCH = subclinical hypothyroidism; TC = total cholesterol;

TG = triglyceride; TSH = thyroid-stimulating hormone.