Table 3.

Neuropathological characteristics of the study subjects on variables not used in uniform manifold approximation and projection (UMAP) dimensionality reduction method by clusters, National Alzheimer’s Coordinating Center (NACC) data through the March 2020 data freeze (n = 495)

Variable	Cluster 1 (n = 103)	Cluster 2 (n = 71)	Cluster 3 (n = 114)	Cluster 4 (n = 207)
TDP-43 pathology, n (%)
Amygdala
No	13 (16.0)	7 (13.5)	8 (8.8)	14 (8.1)
Yes	68 (84.0)	45 (86.5)	83 (91.2)	158 (91.9)
Hippocampus
No	8 (8.2)	5 (7.2)	15 (13.3)	48 (23.4)
Yes	90 (91.8)	64 (92.8)	98 (86.7)	157 (76.6)
Neocortex
No	21 (23.3)	42 (70.0)	86 (80.4)	156 (83.9)
Yes	69 (76.7)	18 (30.0)	21 (19.6)	30 (16.1)
NIA-AA ADNC (ABC score)
Not AD	45 (43.7)	4 (5.6)	1 (0.9)	0 (0)
Low ADNC	56 (54.4)	10 (14.1)	5 (4.4)	3 (1.4)
Intermediate ADNC	2 (1.9)	31 (43.7)	12 (10.5)	15 (7.2)
High ADNC	0 (0)	26 (36.6)	96 (84.2)	189 (91.3)
FTLD-TDP, n (%)
No	24 (23.3)	59 (83.1)	109 (95.6)	196 (94.7)
Yes	79 (76.7)	12 (16.9)	5 (4.4)	11 (5.3)
Hippocampal sclerosis, n (%)
No	68 (66.7)	41 (57.7)	69 (62.2)	139 (67.8)
Yes	34 (33.3)	30 (42.3)	42 (37.8)	66 (32.2)
Whole brain weight (g), mean ± SD	1079.6 ± 175.8	1123.2 ± 201.1	1132.5 ± 158.2	1130.5 ± 159.7
Cerebral cortex atrophy, n (%)
None	12 (15.0)	10 (14.3)	14 (12.7)	18 (9.2)
Mild	16 (20.0)	28 (40.0)	39 (35.5)	57 (29.2)
Moderate	20 (25.0)	21 (30.0)	42 (38.2)	66 (33.8)
Severe	32 (40.0)	11 (15.7)	15 (13.6)	54 (27.7)
Lobar atrophy, n (%)
None	25 (29.4)	50 (72.5)	86 (78.2)	150 (77.3)
Yes	60 (70.6)	19 (27.5)	24 (21.8)	44 (22.7)

SD = standard deviation; NIA-AA = National Institute on Aging - Alzheimer’s Association; ADNC = Alzheimer disease neuropathologic change; FTLD-TDP = frontotemporal lobar degeneration with TDP-43 pathology