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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Acta Neuropathol. 2020 Aug 14;140(5):659–674. doi: 10.1007/s00401-020-02211-0

Table 4.

Feature of each of the clusters

Cluster Feature
1 Enriched for FTLD-TDP and FTD clinically
2 Lower neuritic amyloid plaques, died at older age
3 Most with severe ADNC who died at older age
4 Most with severe ADNC who died at younger age

FTLD-TDP = frontotemporal lobar degeneration with TDP-43 proteinopathy; FTD = frontotemporal dementia; ADNC = Alzheimer’s disease neuropathologic change