Fig. 1.

Mechanism of interorgan protein-protein perturbation transmission. Once the SARS CoV-2 enters the cells in the lungs it uncoates and discharges its RNA and proteins into the human cell cytosol (Step 1). Viral proteins interact with human proteins as illustrated for the case of the viral protein E interacting with human protein BRD4. Some of the perturbed human proteins (or its complex with a viral protein) are then encapsulated into exosomes, which are liberated from lungs cells via exocytosis (Step 2). The exosomes containing a perturbed human protein (or its complex with a viral protein) navigates to another organ where they enter via endocytosis (Step 3). Once in the interior of the cell of another organ the perturbed human protein is discharged into the cytosol and it navigates subdiffusively (Step 4) until it encounters an unperturbed protein expressed mainly in this organ. This interaction perturbs the protein NSD2 which is vulnerable and may trigger a damage at this organ (Step 5).