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Proof of concept. Simulated mixture of IgA nephropathy (IgAN) and UK Biobank (UKBB) control in different percentage mixture. Data are sampled with replacement from IgAN cases (UK Glomerulonephritis DNA Bank [UKGDM] and UKBB) and UKBB control to generate these mixtures. The mean genetic risk score (GRS) is then calculated (red) and the estimated prevalence was calculated using our equation. The simulation mixture matches the calculated estimated prevalence.
