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TRIM proteins display a common domain architecture. A. Common domain architectures of TRIMs, which consist of RING, B-boxes 1 and 2 (B1 and B2) and coiled-coil (CC). C-terminal domains are often involved in substrate recognition and are variable. B. Structures and functions of RING (PDB:5FEY, [23]), B-box (PDB: 5IEA, [25]) and coiled-coil domains (PDB: 6FLN, [29]). Yellow regions in CC (orange) indicate the linker C-terminal to TRIM CC that often folds back onto CC.
