Table 1.
Characteristics of the study population (N = 561)
| Age (years), mean (SD), [range] | 57.4 (7.5) |
| [44–75 years] | |
| Female sex, n (%) | 342 (60.9) |
| Education (years), Mean (SD) | 13.7 (3.5) |
| Hypertension a, n (%) | 147 (26.2) |
| Diabetesb, n (%) | 28 (5.0%) |
| Hypercholesterolemiab, n (%) | 171 (30.5) |
| BMI (kg/m2), mean (range) | 26.4 (24.0–29.4) |
| CAIDE-I risk (%) | 1.47 |
| Number of APOE-ε4 alleles, n (%) | |
| None | 275 (49.0) |
| One APOE-ε4 alleles | 215 (38.3) |
| Two APOE-ε4 alleles | 71 (12.6) |
| TIV (106 cc), median [Q1-Q3] | 1420 [1330–1490] |
| WMH volume (103mm3), median [Q1-Q3] | 1.94 [1.13–3.69] |
| Medial temporal Atrophy scale (MTA), mean (SD) | 0.79 (0.64) |
| Cognitive evaluation, Mean (SD) | |
| Memory binding test | |
| Total Paired Recall (0–32) | 24.2 (4.5) |
| Total Free Recall (0–32) | 16.6 (5.2) |
| Paired Recall Pairs (0–16) | 9.2 (3.4) |
| Total Delayed Free Recall (0–32) | 16.9 (5.2) |
| Total Delayed Paired Recall (0–32) | 23.9 (4.6) |
| Pairs in Delayed Free Recall (0–16) | 6.4 (3.1) |
| Semantic Proactive Interference (%) | 75.2 (18.6) |
| WAIS-IV subtests | |
| Visual Puzzles (0–26) | 13.3 (4.2) |
| Digit Span Forward (0–16) | 8.5 (2.1) |
| Digit Span Backward (0–16) | 8.0 (2.1) |
| Digit Span Sequencing (0–16) | 8.4 (2.1) |
| Matrix Reasoning (0–26) | 16.3 (4.3) |
| Similarities (0–36) | 22.6 (4.7) |
| Coding (0–135) | 65.5 (15.0) |
aSystolic blood pressure > 140 mmHg
bMedications and/or self-reported