Table 2.
Correlation between global WMH load and cognition
| Rho [95% CI] | p | |
|---|---|---|
| Cognitive z-score composites | ||
| Memory | −0.07 [−0.156–0.001] | 0.04* |
| Executive function | −0.07 [−0.152–0.012] | 0.04* |
| Memory binding test | ||
| Total free recall | −0.05 [−0.131–0.029] | 0.12 |
| Total delayed free recall | −0.07 [−0.156–0.001] | 0.04* |
| Total paired recall | −0.05 [−0.130–0.037] | 0.14 |
| Total delayed paired recall | −0.07 [−0.155 - -0.001] | 0.04* |
| Paired recall pairs | −0.06 [−0.146–0.019] | 0.07¥ |
| Pairs in delayed free recall | −0.08 [−0.166 - -0.001] | 0.03* |
| Semantic proactive interference | −0.08 [−0.161–5.5e-05] | 0.03* |
| Subtests of WAIS-IV | ||
| Digit span forward | −0.01[−0.090–0.079] | 0.42 |
| Digit span backward | −0.09 [−0.174 - -0.001] | 0.01* |
| Digit span sequencing | 0.03 [−0.056–0.110] | 0.28 |
| Coding | −0.06 [−0.135–0.023] | 0.08¥ |
| Visual puzzles | −0.01 [−0.095–0.070] | 0.39 |
| Matrix reasoning | −0.05 [−0.129–0.031] | 0.12 |
| Similarities | −0.06 [−0.143–0.024] | 0.08¥ |
Adjusted by age, sex, education and number of APOE-ε4 alleles. WMH also adjusted by TIV.
*p < 0.05
¥Significant trend (p ≤ 0.1)