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. 2020 Oct 19;10:17617. doi: 10.1038/s41598-020-74091-z

Table 1.

Classification of codon boxes.

Type of codon box Codon box Amino acid Codon
Type-1 {aaa} Lys AAA
{ccc} Pro CCC
{ggg} Gly GGG
{ttt} Phe TTT
Type-2 {aac} Gln, Asn, Thr CAA, AAC, ACA
{aag} Arg, Glu, Lys AGA, GAA, AAG
{aat} Ile, Asn ATA, AAT
{acc} His, Pro, Thr CAC, CCA, ACC
{agg} Arg, Glu, Gly AGG, GAG, GGA
{att} Ile, Leu, Tyr ATT, TTA, TAT
{ccg} Ala, Arg, Pro GCC, CGC, CCG
{cct} Leu, Pro, Ser CTC, CCT, TCC
{cgg} Ala, Arg, Gly GCG, CGG, GGC
{ctt} Leu, Phe, Ser CTT, TTC, TCT
{ggt} Gly, Trp, Val GGT, TGG, GTG
{gtt} Cys, Leu, Val TGT, TTG, GTT
Type-3 {acg} Ala, Arg, Asp, Gln, Ser, Thr GCA, CGA, GAC, CAG, AGC, ACG
{act} His, Ile, Leu, Ser, Thr, Tyr CAT, ATC, CTA, TCA, ACT, TAC
{agt} Asp, Met, Ser, Val GAT, ATG, AGT, GTA
{cgt} Ala, Arg, Cys, Leu, Ser, Val GCT, CGT, TGC, CTG, TCG, GTC

According to the codon box concept, 64 codons can be divided into 20 kinds of codon boxes. Furthermore, the codon boxes can be classified into three categories: Type-1 has only one kind of base; Type-2 has two kinds of bases; and Type-3 has three kinds of bases.