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. 2020 Oct 19;5:242. doi: 10.1038/s41392-020-00359-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The exosome-mediated metabolic reprogramming in the tumor microenvironment. Exosome-mediated metabolic reprogramming occurs in cancer cells and their surrounding stromal cells in the TME. Stromal cells metabolic reprogramming is affected by exosomes derived from cancer cells, and acts as a feedback loop to drive metabolic changes in cancer cells or to provide metabolic resources required for cancer progression