Protein |
PKM2, GLUT1 |
LPS-activated LX-2 and activated primary HSCs |
HSCs, KCs, and LSECs |
Induces the glycolysis of quiescent HSCs LSECs and KCs |
138 |
|
PKM2 |
LNCaP, PC3, and C4-2B |
ST2, mouse BMSCs |
Creates a pre- metastatic niche through transferring PKM2 |
80 |
|
VEGF |
HL-60, U937, primary AML cells |
HUVECs |
Promotes chemoresistance by inducing the glycolysis in HUVECs |
72 |
|
ALDOA, ALDH3A1 |
Irradiated A549 and NCI-H446 |
Unirradiated A549 and NCI-H446 |
Enhances the motility of the recipient cells by promoting the glycolysis |
97 |
|
LMP1 |
CM |
CAFs |
Increases the glycolysis and autophagy in CAFs |
54 |
|
ITGB4 |
MDA-MB-231, BT-20 |
CAFs |
Promotes the glycolysis and the export of lactate in CAFs |
52 |
|
FAO-related proteins |
Adipocytes |
SKMEL28 and 1205Lu |
Promotes tumor aggressiveness by inducing fatty acid oxidation |
67 |
|
AM |
PC patient-derived cell lines |
Adipocytes |
Induce lipolysis |
139 |
miRNA |
miR-105 |
MCF10A and MDA-MB-231 |
NIH3T3 and WI-38 |
Promotes tumor growth by reprogramming the metabolism of CAFs |
53 |
|
miR-122 |
MCF10A and MDA-MB-231 |
Mouse lung fibroblasts and Mouse astrocytes |
Remodels metabolism of the niche cells to promote tumor progression |
115 |
|
miR-155 |
4 T-1, C2C12 and HEK 293T |
3 T3-L1 |
Induces the beige/brown differentiation and promotes lipolysis in the adipocytes |
64 |
|
miRNAs |
KSHV-infected LECs |
HUVEC and LEC |
Promotes the glycolysis in the non-infected cells. |
106 |
|
miR-155, miR-210 |
1770-Her4, 2183-Her4, 1300-mel, HMCB, 526-mel, 888-mel, and Hs 294T |
HADF |
Promotes the tumor metastasis through enhancing the glycolysis in stromal cells |
114 |
|
miR-126, miR-144 |
MCF-7, MDA-MB-231, and HEK 293T |
3T3-L1 |
Inducing the metabolic reprogramming in adipocytes to promote tumor progression |
65 |
lncRNA |
SNHG3 |
Breast cancer patient-derived fibroblast cells |
MCF-7 and MD-MBA-453 |
Promotes the tumor growth by reprogramming the metabolism of breast cancer cells |
98 |
|
HISLA |
TAMs |
MDA-MB-231, MDA-MB-468, BT-474, and MCF-7 |
Enhances the glycolysis and chemoresistance of breast cancer cells |
93 |
circRNA |
ciRS-122 |
SW480/oxaliplatin (L-OHP) and HCT116 /L-OHP |
SW480 and HCT116 |
Increases the glycolysis and decreases drug sensitivity in the sensitive cancer cells |
119 |
Metabolite |
Lactate, glutamate |
hMSCs |
MCF-7 |
Promote the tumor growth |
144 |