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. 2020 Oct 19;10:17599. doi: 10.1038/s41598-020-74718-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intrinsic differences in matrix dehydrogenase activity and expression across tissues. (A) Cartoon depicting the matrix dehydrogenases, and associated enzymes, network. (B) Enzyme activity normalized to total protein and corrected for each sample’s MEF. (C) MitoCarta 2.0 normalized protein expression of individual enzyme subunits. (A) Figure created with BioRender.com. (B,C) Figure generated using GraphPad Prism 8 software (Version 8.4.2). Data information: Data are presented as mean ± SEM, N = 5/group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.