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. 2020 Oct 19;11:5270. doi: 10.1038/s41467-020-18965-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Chromatin states observed in two primary PDAC tumor tissues as determined by 6 histone markers; H3K4me1, H3K4me3, H3K9me3, H3K27ac, H3K27me3, and H3K36me3. b Box plots depicting 5hmC occupancy in PDAC (n = 41) and non-cancer (NC, n = 38) cfDNA cohorts over the chromatin states determined in PDAC primary tissue samples. Center line represents median, bounds of box represent 25th and 75th percentiles and whiskers are Tukey whiskers. Statistical significance in PDAC vs non-cancer cfDNA enrichment, as determined by two-sided Wilcoxon test, is denoted by ** (p value < 0.00001) and * (p value < 0.0001). p-values are 1.85E−06 (active TSS), 1.28E−06 (flanking active TSS), 8.59E−06 (weak transcription), 4.28E−05 (weak enhancer) and 2.51E−05 (quiescent).