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. 2020 Oct 19;11:5270. doi: 10.1038/s41467-020-18965-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Average 5hmC FPKM values over top 50 hyper-hydroxymethylated (hyper-hme) genes with the highest 5hmC occupancy compared with the top 50 hypo-hydroxymethylated (hypo-hme) genes with the lowest 5hmC occupancy in PDAC tumor tissues (n = 17). Boxplot center lines represent median, bounds of box represent 25th and 75th percentiles and whiskers are Tukey whiskers. Each dot represents an individual PDAC tumor tissue. b PCA plots showing non-cancer (blue) and PDAC (red) cfDNA cohorts using top 50 hyper-hydroxymethylated (upper panel) and top 50 hypo-hydroxymethylated (bottom panel) genes as features. c ROC curves for predictive model using features discovered in cfDNA (teal), top 50 genes with highest 5hmC representation in tissue (solid coral), or 50 genes with lowest 5hmC representation in tissue (dotted coral). d Heatmap showing FPKM values of all the gene features (n = 37) used in cfDNA prediction model (represented in each row) in non-cancer cfDNA, PDAC cfDNA, and PDAC tissue 5hmC profiles (represented in each column).