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. 2020 Oct 19;11:5278. doi: 10.1038/s41467-020-19096-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Eight- to 16-week-old hSTAT2 KI female and male mice were mated. On E6.5, plugged females were administered 250 μg of the indicated murine (a–c) or human (d–f) mAbs and inoculated subcutaneously with 10⁶ FFU of ZIKV. For experiments with antibody cocktail treatment, mice received 125 μg of each mAb. Viral burden was assessed on E13.5 in maternal spleen (a, d), placenta (b, e), and fetal head (c, f). Viral burden data for the maternal spleen includes mice that were plugged but did not become pregnant. For each pregnant dam, five placentas and fetal heads were evaluated unless the total number of fetuses was less than 5. a Isotype, n = 16; Z15, n = 4; Z17, n = 6; Z15 + Z17, n = 7. b, c Isotype, n = 61; Z15 n = 20; Z17, n = 28; Z15 + Z17, n = 35. d Isotype, n = 9; ZIKV-292, n = 4; 749-A4 and 749-A4 LALA, n = 5. e, f Isotype, n = 45; ZIKV-292, n = 26; 749-A4, n = 20; 749-A4 LALA, n = 25. Data are pooled from at least three experiments (Kruskal–Wallis one-way ANOVA with Dunn’s post-test comparison between the indicated groups; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; a isotype vs. Z15 + Z17, p = 0.010; b isotype vs. Z17, p = 0.0006; isotype vs. Z15 + Z17, p < 0.0001; c isotype vs. Z17, p < 0.0001; isotype vs. Z15 + Z17, p < 0.0001; d isotype vs. ZIKV-292, p = 0.048; e isotype vs. ZIKV-292, p < 0.0001; isotype vs. 749-A4, p = 0.004; f isotype vs. ZIKV-292, p < 0.0001; isotype vs. 749-A4, p = 0.0003; 749-A4 vs. 749-A4 LALA, p = 0.002). Dotted lines denote the LOD.