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. 2020 Oct 19;10:17594. doi: 10.1038/s41598-020-74695-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reactive oxygen species (ROS) generation and activated caspase 3/7 in response to HHP treatment. (a) Left: representative histograms of the fluorescence expression of MitoSOX Red among the control, STS-treated and various time exposure of 0 MPa groups. Right: representative histograms of the fluorescence expression of MitoSOX Red among the control, STS-treated and HHP-exposed and unexposed groups. (b) Diagram comparing the MFI of ROS elevation among groups (n = 3). (c) Immunofluorescence images of ROS production stained by MitoSOX Red mitochondria indicator and Hoechst 33,342 showing the generation of a ROS signal after 50-MPa treatment for 24, 36 or 48 h. Scale bar: 20 μm. Data are representative of at least three independent experiments. (d) Activated caspase 3/7 fluorescence expression and ratio of caspase positivity between groups without HHP (0 MPa) and with 50 MPa for 36 h (n = 3).