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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Allergy Clin Immunol. 2020 Apr 15;146(6):1406–1418.e7. doi: 10.1016/j.jaci.2020.03.032

Figure 8. Model of TSLP mediated acute CD4 T cell driven airway inflammation via CD11cIM.

Figure 8.

Following exposure with TSLP and antigen in the lungs, both CD11cIM and DC uptake antigen. Antigen-bearing DC migrate into the LdLN, whereas CD11cIM remain in the lungs. In the LdLN, Th2 that are generated by DC play a limited role for the acute inflammation in the lungs. In contrast, in the lungs, direct TSLP/TSLPR signal increases the potency of CD11cIM as APC for promoting differentiation of naïve CD4 T cells into primary effector Th2 cells and subsequent acute eosinophilic airway inflammation.