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. 2020 Oct 19;10:17649. doi: 10.1038/s41598-020-74806-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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P-AscH⁻ attenuates the invasive phenotype of PDAC in vitro. Cells were treated with P-AscH⁻ or P-AscH⁻ + catalase (200 U/mL) for 1 h then seeded at 1–3 × 10⁵ and incubated for 24 (PANC-1) or 48 h (BxPC-3 and 339). Data represent mean of invaded cells/field compared to control ± SE (n = 5, *p < 0.05; one-way ANOVA with Bonferroni’s multiple comparisons). (A) Representative invasion images from BxPC-3 PDAC cells in the presence of P-AscH⁻ and/or catalase. (B) P-AscH⁻ (2 mM for 1 h) decreased the percentage of invading BxPC-3 cells by 42% (255 +/− 23 cells vs 107 ± 15 cells). (C) P-AscH⁻ (4 mM for 1 h) decreased the percentage of invading 339 patient derived PDAC cells by 41.5% (231 ± 11.5 cells vs 96 +/− 6 cells). (D) P-AscH⁻ (4 mM for 1 h) decreased the percentage of invading Panc-1 PDAC cells by 34% (455 +/− 16.5 cells vs 151 +/− 30 cells).