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. 2020 Oct 19;10:17649. doi: 10.1038/s41598-020-74806-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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P-AscH⁻ treatment attenuates nuclease activity in patients with metastatic PDAC. Subjects with metastatic PDAC treated with P-AscH⁻ had decreases in nuclease activity compared to subjects with local and regional disease treated with P-AscH⁻. (A) Subjects in the University of Iowa clinical trial (NCT 01049880) treated with P-AscH⁻ and gemcitabine had decreased nuclease activity over time. Initial nuclease activity was compared to nuclease activity at weeks 4 and 7 of treatment. Data represent the mean nuclease activity compared to control ± SE (n = 9, *p < 0.05; unpaired Students T-test). (B) Subjects in the University of Iowa clinical trial (NCT 01852890) treated with P-AscH⁻, gemcitabine, and radiation showed minimal differences in nuclease activity. Initial activity was compared to activity at weeks 4 and 7 of treatment (n = 9, p > 0.05; unpaired Students T-test).