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. Author manuscript; available in PMC: 2020 Nov 14.
Published in final edited form as: Prostate Cancer Prostatic Dis. 2020 Apr 20;23(4):661–669. doi: 10.1038/s41391-020-0229-z

Fig. 3.

Fig. 3

The expression of YAP1 in human prostatic tissues. (A) Benign prostatic tissue demonstrated positive YAP1 staining in the stroma cells and basal cells (indicated by the arrows). (B) Low-grade prostate adenocarcinoma. YAP1 expression was present in stromal cells and occasional basal cells (indicated by the arrow) but was absent in adenocarcinoma cells. (C) High-grade prostate adenocarcinoma. YAP1 was expressed in prostate adenocarcinomas (indicated by the arrows) with a Gleason score of 8 or higher. (D to F) Serial sections of a NEPC with focal adenocarcinoma. YAP1 protein was expressed in high-grade adenocarcinoma components (indicated by the # sign), but the expression was lost in NEPC cells. CHGA and FOXA2 were diffusely expressed in NEPC but not in adenocarcinoma cells. (G to I) Serial sections of a small cell carcinoma demonstrating negative YAP1 and positive synaptophysin (SYP) staining in NEPC cells. (J) Distribution of YAP1 expression (H-score) among PCa with various Gleason grade. The expression of YAP1 was associated with Gleason score (Spearman correlation test, r=0.4962, p<0.0001).