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. Author manuscript; available in PMC: 2020 Oct 20.
Published in final edited form as: Curr Pharm Des. 2020;26(34):4330–4337. doi: 10.2174/1381612826666200415171622

Figure 3. BAY-60–6583 reverses midazolam induced cognitive deficits.

Figure 3.

Wildtype (C57BL6/J) mice were injected with either saline, midazolam (10mg/kg i.p.), or midazolam + BAY 60–6583 (1 μg/kg i.p.) and compared to saline-treated controls. 2 hours later mice underwent brain PER2 mRNA analysis. 24 hours later, mice underwent behavioral studies using T-maze alternation tests. (A) The molecular formula of BAY 60–6583, a specific ADORA2B agonist. (B) Hippocampal PER2 transcript levels 24hours after midazolam or midazolam + BAY 60–6583 administration (n=5; p<0.05). (C) T-maze alternation in % 24 hours after a single dose of midazolam or midazolam + BAY 60–6583 (n=4–10; p<0.05). All data are presented as mean ± SD.