(A-D) Brain hippocampus tissue was harvested from wildtype (C57BL6/J) or Adora2b−/− mice, mRNA was isolated using RNeasy Mini Kit (Qiagen), cDNA was generated using miScript RT II kits (Qiagen), and Tnf-α. (A), Il-6 (B), Bdnf (C) and C-fos (D) transcript levels were determined by quantitative real-time RT-PCR (iCycler or iCycler IQ; Bio-Rad Laboratories Inc.), n=4–5, p<0.05, all data are presented as mean ± SD.