. Author manuscript; available in PMC: 2021 Sep 1.

Published in final edited form as: Arthritis Rheumatol. 2020 Aug 6;72(9):1483–1492. doi: 10.1002/art.41291

Table 2:

Genetic association analysis between RA and IVWR phenotypes

Phenotypes	# SNPs	IVWR		Egger regression

		OR [95%CI]	P-value	OR [95%CI]	P-value	I.E.	P-value^a

T1D
All RA SNPs^b	^*	^*	^*	^*	^*	^*	^*
Excluding MHC SNPs	99	1.67 [1.47, 1.90]	1.15×10⁻¹⁴	2.61 [1.96, 3.49]	6.92×10⁻¹¹	−0.056	0.001
Excluding rs2476601	98	1.47 [1.29, 1.68]	9.53×10⁻⁹	1.50 [0.90, 2.48]	0.117	−0.002	0.939

T2D
All RA SNPs^b	230	1.03 [1.02, 1.04]	1.11×10⁻⁹	1.04 [1.03, 1.06]	6.94×10⁻⁸	−0.003	0.055
Excluding MHC SNPs	136	1.03 [1.00, 1.05]	0.020	1.04 [0.98, 1.09]	0.170	−0.001	0.612

CRP
All RA SNPs^b	226	1.02 [1.01, 1.03]	1.72×10⁻⁶	1.02 [1.01, 1.04]	0.001	−0.001	0.566
Excluding MHC SNPs	136	1.02 [1.00, 1.04]	0.033	1.01 [0.97, 1.06]	0.620	0.001	0.753

CAD
All RA SNPsb^a	230	1.02 [1.01, 1.03]	3.83×10⁻⁴	1.02 [1.00, 1.04]	0.031	0.000	0.924
Excluding MHC SNPs	136	1.01 [0.99, 1.04]	0.258	1.01 [0.95, 1.08]	0.706	0.000	0.979

RA: rheumatoid arthritis; T1D: Type 1 diabetes; T2D: Type 2 diabetes; CRP: C-reactive protein; CAD: coronary artery disease; SNP: single nucleotide polymorphism; IVWR: Inverse weighted variance regression; OR: odds ratio; 95%CI: 95% confidence interval. I.E.: Intercept estimate for the Egger regression.

P-value for the intercept.

Includes independent SNPs (R²<0.05) that were previously associated with rheumatoid arthritis (RA) at P <5×10⁻⁶.

Summary statistics for T1D already excluded the MHC region.