Skip to main content
. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Pain. 2020 Nov;161(11):2539–2550. doi: 10.1097/j.pain.0000000000001953

Figure 3. Repeated stress induces transient priming to SNP in male and female mice.

Figure 3.

Facial withdrawal thresholds were measured in (A) male and (B) female mice following acute stress (n = 8 male, 8 female). Following the final day of stress, animals were tested out to 35 days and received either 0.1 mg/kg SNP (n = 8 males, n = 9 females) or vehicle (n = 9 males, n = 8 females). All controls received SNP. (†) denotes statistical significance between stressed mice will receive SNP and control mice. (*) denotes statistical significance between stressed mice that will receive vehicle and control mice. (§) denotes statistical significance between stressed mice that received vehicle and stressed miced that received SNP. Two-way RM ANOVA with Bonferroni multiple comparison analysis indicated a significant difference between stressed and control mice in the acute phase, but revealed no significant differences following administration of SNP. Data are represented as means ± SEM. *p<0.05, ††††,****p<0.0001. See Table 2 for additional results of analysis.