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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Pain. 2020 Nov;161(11):2539–2550. doi: 10.1097/j.pain.0000000000001953

Table 2.

Statistical Analyses Results

Figure Analysis Statistics
Fig. 1A Two-way repeated measure ANOVA
Interaction Factor F(10, 115)=12.04, p<0.0001
BL-BL Time Factor F(3.008, 69.19)=50.31, p<0.0001
Treatment Factor F(2, 23)=28.16, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 1A Two-way repeated measure ANOVA
Interaction Factor F(4, 46)=3.862, p=0.0087
SNP 1–24hr Time Factor F(1.854, 42.63)=6.911, p=0.0031
Treatment Factor F(2, 23)=1.685, p=0.2075
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 1B Two-way repeated measure ANOVA
Interaction Factor F(10, 89)=36.19, p<0.0001
BL-BL Time Factor F(2.822, 50.23)=180.0, p<0.0001
Treatment Factor F(2, 18)=149.7, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 1B Two-way repeated measure ANOVA
Interaction Factor F(6, 54)=3.952, p=0.0024
SNP 1–24hr Time Factor F(1.799, 32.37)=2.446, p=0.1074
Treatment Factor F(2, 18)=14.38, p=0.0002
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 1C Two-way repeated measure ANOVA
Interaction Factor F(5, 130)=35.53, p<0.0001
BL-BL Time Factor F(2.574, 66.93)=42.04, p<0.0001
Treatment Factor F(1, 26)=124.6, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 1C Two-way repeated measure ANOVA
Interaction Factor F(3, 78)=1.571, p=0.2032
SNP 1–24hr Time Factor F(2.6, 67.60)=7.452, p=0.0004
Treatment Factor F(1, 26)=4.448, p=0.0447
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 2A Two-way repeated measure ANOVA
Interaction Factor F(12, 138)=1.608, p=0.0961
Time Factor F(3.257, 74.91)=4.811, p=0.0032
Treatment Factor F(2, 23)=0.1607, p=0.8525
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 2B Two-way repeated measure ANOVA
Interaction Factor F(12, 108)=0.7945, p=0.6652
Time Factor F(3.763, 67.74)=0.9845, p=0.4186
Treatment Factor F(2, 18)=2.249, p=0.1343
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 3A Two-way repeated measure ANOVA
Interaction Factor F(16, 176)=33.03, p<0.0001
BL-35D Time Factor F(4.232, 93.11)=144.2, p<0.0001
Treatment Factor F(2, 22)=170.6, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 3A Two-way repeated measure ANOVA
Interaction Factor F(6, 66)=1.526, p=0.1834
SNP1–72hr Time Factor F(2.334, 51.35)=0.7346, p=0.5043
Treatment Factor F(2, 22)=0.2865, p=0.7537
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 3B Two-way repeated measure ANOVA
Interaction Factor F(18, 198)=16.84, p<0.0001
BL-35D Time Factor F(4.475, 98.44)=76.59, p<0.0001
Treatment Factor F(2, 22)=78.94, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 3B Two-way repeated measure ANOVA
Interaction Factor F(8, 88)=0.8713, p=0.5439
SNP 1–72hr Time Factor F(2.849, 62.69)=2.019, p=0.1233
Treatment Factor F(2, 22)=0.5833, p=0.5664
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 4A Two-way repeated measure ANOVA
Interaction Factor F(20, 130)=59.77, p<0.0001
BL-14D Time Factor F(3.744, 97.34)=222.8, p<0.0001
Treatment Factor F(2, 26)=392.2, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 4A Two-way repeated measure ANOVA
Interaction Factor F(10, 130)=3.467, p=0.0005
SNP 16D-72hr Time Factor F(3.448, 89.64)=15.26, p<0.0001
Treatment Factor F(2, 26)=10.56, p=0.0004
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 4B Two-way repeated measure ANOVA
Interaction Factor F(10, 105)=76.44, p<0.0001
BL-14D Time Factor F(3.171, 66.58)=408.3, p<0.0001
Treatment Factor F(2, 21)=278.4, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 4B Two-way repeated measure ANOVA
Interaction Factor F(10, 105)=5.245, p<0.0001
SNP 16D-72hr Time Factor F(3.279, 68.86)=6.289, p=0.0005
Treatment Factor F(2, 21)=17.62, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 5 Two-way repeated measure ANOVA
Interaction Factor F(18, 156)=28.96, p<0.0001
BL-14D Time Factor F(3.536, 91.93)=264.0, p<0.0001
Treatment Factor F(3, 26)=341.9, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 5 Two-way repeated measure ANOVA
Interaction Factor F(12, 108)=4.287, p<0.0001
SNP+Suma 1–72hr Time Factor F(3.430, 92.62)=8.103, p<0.0001
Treatment Factor F(27, 108)=, p=0.0105
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 6A Two-way repeated measure ANOVA
Interaction Factor F(12, 172)=26.66, p<0.0001
BL-14D Time Factor F(3.108, 133.6)=94.04, p<0.0001
Treatment Factor F(3, 43)=64.93, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 6A Two-way repeated measure ANOVA
Interaction Factor F(6, 86)=3.244, p=0.0064
pH 1–24hr Time Factor F(1.915, 82.33)=1.063, p=0.3478
Treatment Factor F(3, 43)=27.50, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 6B Two-way repeated measure ANOVA
Interaction Factor F(12, 112)=14.27, p<0.0001
BL-14D Time Factor F(2.616, 73.25)=55.79, p<0.0001
Treatment Factor F(3, 28)=60.03, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Fig. 6B Two-way repeated measure ANOVA
Interaction Factor F(6, 56)=1.494, p=0.1970
pH 1–24hr Time Factor F(1.929, 54.01)=5.457, p=0.0075
Treatment Factor F(3, 28)=2.769, p=0.0478
Bonferroni’s multiple comparisons between treatments (see figure legend)
Suppl. Fig. A. Two-way repeated measure ANOVA
Interaction Factor F(7, 63)=12.15, p<0.0001
BL-14D Time Factor F(2.811, 25.30)=11.19, p<0.0001
Treatment Factor F(1,9)=80.78, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Suppl. Fig. A. Two-way repeated measure ANOVA
Interaction Factor F(4, 36)=1.241, p=0.3110
SNP 1–72hr Time Factor F(2.242, 20.18)=1.263, p=0.3075
Treatment Factor F(1, 9)=2.299, p=0.0011
Bonferroni’s multiple comparisons between treatments (see figure legend)
Suppl. Fig. B. Two-way repeated measure ANOVA
Interaction Factor F(7, 70)=7.490, p<0.0001
BL-14D Time Factor F(3.211, 32.11)=9.698, p<0.0001
Treatment Factor F(1, 10)=55.15, p<0.0001
Bonferroni’s multiple comparisons between treatments (see figure legend)
Suppl. Fig. B. Two-way repeated measure ANOVA
Interaction Factor F(4, 40)=7.378, p=0.0002
SNP 1–72hr Time Factor F(2.829, 28.29)=2.544, p=0.0791
Treatment Factor F(1, 10)=31.81, p=0.0002
Bonferroni’s multiple comparisons between treatments (see figure legend)