Table 1.
Cohort Demographics
| Full Cohort | At least one MELD-Na score | Ever-listed | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | p | Male | Female | p | Male | Female | p | ||
| n | 11501 | 8544 | 6393 | 4120 | 1106 | 634 | ||||
| Age (mean (SD))# | 56.5 (11.2) | 58.0 (12.4) | <0.001 | 55.7 (10.9) | 57.2 (12.0) | <0.001 | 55.6 (9.8) | 55.9 (10.5) | 0.511 | |
| Mean Days of follow up time* # | 883 | 991 | <0.001 | 872 | 1000 | <0.001 | 820 | 1024 | <0.001 | |
| Race n (%)^ | <0.001 | <0.001 | 0.451 | |||||||
| White | 5278 (45.9) | 3835 (44.9) | 2728 (42.7) | 1753 (42.5) | 698 (63.1) | 407 (64.2) | ||||
| Black | 2354 (20.5) | 2064 (24.2) | 1259 (19.7) | 972 (23.6) | 85 (7.7) | 58 (9.1) | ||||
| Hispanic | 2000 (17.4) | 1272 (14.9) | 1307 (20.4) | 730 (17.7) | 132 (11.9) | 79 (12.5) | ||||
| Asian | 318 (2.8) | 209 (2.4) | 187 (2.9) | 104 (2.5) | 35 (3.2) | 18 (2.8) | ||||
| Other | 1551 (13.5) | 1164 (13.6) | 912 (14.3) | 561 (13.6) | 156 (14.1) | 72 (11.4) | ||||
| Insurance n (%)^ | <0.001 | <0.001 | 0.235 | |||||||
| Medicare/Medicaid | 5418 (47.1) | 4592 (53.7) | 2834 (44.3) | 2126 (51.6) | 615 (55.6) | 368 (58.0) | ||||
| Private | 3946 (34.3) | 2900 (33.9) | 1973 (30.9) | 1271 (30.8) | 423 (38.2) | 219 (34.5) | ||||
| Other | 2137 (18.6) | 1052 (12.3) | 1586 (24.8) | 723 (17.5) | 68 (6.1) | 47 (7.4) | ||||
| Elixhauser score37 (mean (SD))$ | 4.03 (3.41) | 3.99 (3.58) | 0.463 | 4.24 (3.32) | 4.32 (3.47) | 0.246 | 5.17 (3.44) | 5.34 (3.55) | 0.316 | |
| Etiology n(%)^ | HCV | 5047 (43.9) | 3077 (36.0) | <0.001 | 2809 (43.9) | 1555 (37.7) | <0.001 | 537 (48.6) | 264 (41.6) | 0.006 |
| Alcohol | 4779 (41.6) | 1840 (21.5) | <0.001 | 3427 (53.6) | 1222 (29.7) | <0.001 | 630 (57.0) | 207 (32.6) | <0.001 | |
| NASH | 2442 (21.2) | 2545 (29.8) | <0.001 | 1007 (15.8) | 1034 (25.1) | <0.001 | 98 (8.9) | 127 (20.0) | <0.001 | |
| HBV | 1161 (10.1) | 483 (5.7) | <0.001 | 676 (10.6) | 256 (6.2) | <0.001 | 123 (11.1) | 26 (4.1) | <0.001 | |
| Cholestatic | 708 (6.2) | 1457 (17.1) | <0.001 | 393 (6.1) | 640 (5.5) | <0.001 | 183 (16.5) | 141 (22.2) | 0.004 | |
| Autoimmune | 166 (1.4) | 531 (6.2) | <0.001 | 102 (1.6) | 279 (6.8) | <0.001 | 21 (1.9) | 35 (5.5) | <0.001 | |
| Hemochromatosis | 108 (0.9) | 46 (0.5) | 0.002 | 48 (0.8) | 24 (0.6) | 0.368 | 7 (0.6) | 8 (1.3) | 0.273 | |
| Wilsons | 41 (0.4) | 36 (0.4) | 0.536 | 24 (0.4) | 23 (0.6) | 0.222 | 12 (1.1) | 14 (2.2) | 0.98 | |
| Complication n (%)^ | ||||||||||
| HCC | 1992 (17.3) | 820 (9.6) | <0.001 | 1346 (21.1) | 522 (12.7) | <0.001 | 454 (41.0) | 165 (26.0) | <0.001 | |
| Ascites | 4264 (37.1) | 2623 (30.7) | <0.001 | 2797 (43.8) | 1626 (39.5) | <0.001 | 725 (65.6) | 425 (67.0) | 0.564 | |
| Hepatic Encephalopathy | 4224 (36.7) | 2737 (32.0) | <0.001 | 2804 (43.9) | 1710 (41.5) | 0.02 | 772 (69.8) | 438 (69.1) | 0.8 | |
| Variceal status n (%)^ | <0.001 | 0.001 | 0.398 | |||||||
| No esophageal varices | 8002 (69.2) | 6342 (74.2) | 3987 (62.4) | 2710 (65.8) | 392 (35.4) | 245 (38.6) | ||||
| Varices without bleeding | 3110 (27.0) | 2000 (23.4) | 2217 (34.7) | 1310 (31.8) | 644 (58.2) | 349 (55.0) | ||||
| Variceal Bleeding | 389 (3.4) | 202 (2.4) | 189 (3.0) | 100 (2.4) | 70 (6.3) | 40 (6.3) | ||||
| MELD-Na |  No MELD-Na Score n (%)^ | 5108 (44.4) | 4424 (51.8) | 0.001 | --- | --- | ---- | ---- | ||
|  <15 during follow up n(%)^ | 2754 (43.1) | 2149 (52.2) | <0.001 | 2754 (43.1) | 2149 (52.2) | <0.001 | 257 (23.2) | 158 (24.9) | 0.462 | |
| Min MELD-NA (mean (SD))# | 13.42 (7.07) | 11.87 (6.38) | <0.001 | 13.42 (7.07) | 11.87 (6.38) | <0.001 | 12.54 (6.18) | 11.24 (5.30) | <0.001 | |
| Max MELD-NA (mean (SD))# | 19.03 (9.01) | 17.16 (9.12) | <0.001 | 19.03 (9.01) | 17.16 (9.12) | <0.001 | 23.82 (9.36) | 23.45 (9.37) | 0.433 | |
*
Time at risk was defined as time from first inclusion diagnosis code to the first of transplant, death, or study end.
**
Please see supplement for definitions of categories
#
T-test
^
Chi-Squared test