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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Dev Neurobiol. 2020 Apr 25;81(3):321–332. doi: 10.1002/dneu.22746

Figure 4.

Figure 4.

Severing proteins disassemble microtubules in neurites prior to pruning and degeneration. (Left panel) During competition to innervate muscle fibers, some motor axon terminals are eliminated from fibers. Spastin acts to increase the number of plus ends during elimination to help disassemble the “losing” terminal (81). (Middle panel) During large-scale pruning of Drosophila sensory dendrites, kat-60L1 is required to separate the dendrite from the cell body at its base (91). (Right panel) A different severing protein, fidgetin, is used to increase microtubule dynamics in a cut off dendrite after it is severed from the cell body (52).