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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Trends Biochem Sci. 2020 Jul 17;45(11):961–977. doi: 10.1016/j.tibs.2020.06.007

Figure 5. Sources of Compositional Specificity in Nuclear Condensates.

Figure 5.

This model depicts four types of contributions to compositional specificity: (1) nuclear trafficking; (2) conventional high-affinity structured interactions among proteins; (3) the ability of bifunctional proteins with a condensate-promoting domain to be crowded by binding to multiple sites on a DNA, RNA, or protein substrate; and (4) the various weak multivalent interactions.