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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Brain Behav Immun. 2020 Jul 2;89:245–255. doi: 10.1016/j.bbi.2020.06.028

Figure 5. Microglia depletion aggravates spontaneous seizure induced by KA.

Figure 5.

a, Drug treatment and EEG recording scheme in iDTA and Csf1r mice. b–e, Representative traces and quantification of EEG recordings show that CX3CR1+ cell ablation aggravates spontaneous seizures in iDTA mice (b, c) and Csf1r mice (d, e) starting 28 days after KA treatment. f, Drug treatment and EEG recording scheme in iDTR mice. g–h, Representative traces and quantification of EEG recordings show that specific microglia depletion increases spontaneous seizures in iDTR mice starting 28 days after KA treatment. Data presented as means ± SEM, n=3–4. **P<0.01 vs control group.