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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: J Hepatol. 2020 May 8;73(5):1144–1154. doi: 10.1016/j.jhep.2020.04.044

Fig. 6. SHP2 deletion selectively in HSCs reduces liver fibrosis.

Fig. 6.

(A) Patient liver samples were lysed and analyzed by WB. 3–5 patients/group, WB images cropped from the same blot, graph bars represent SEM, *p<0.05 Mann-Whitney test. (B-C) SHP2fl/fl or SHP2ΔHSC male and female mice were treated with either olive oil or CCl4 for 6 weeks. Livers were analyzed by WB (C) and Sirius red staining (D). (n= 6–8 animals/group) (D-E) C57Bl/6 male and female mice were treated for 4 weeks with phosphate-buffered saline or equal number of EVs derived from donor mice as indicated in parallel with CCl4. Livers were analyzed by WB (E) and Sirius red (F) (n = 7–8 animals/group). Scale bars: 20μm, graph bars represent SEM, one-way ANOVA with Bonferroni comparison **p< 0.01, ***p< 0.001.