Table 2.
Bisphenol and phthalate urinary concentrations (n=1,192)
| Early pregnancy median GA 12.9 wks (IQR 12.1-14.5) |
Mid-pregnancy median GA 20.4 wks (IQR 19.9-20.9) |
|||
|---|---|---|---|---|
| Median (IQR) (ng/mL) | Percentage of values below the limit of detection (LOD) | Median (IQR) (ng/mL) | Percentage of values below the limit of detection (LOD) | |
| Total bisphenolsa | 9.35 (3.53, 20.69) | 6.29 (3.04, 13.71) | ||
| Bisphenol A (BPA) | 1.67 (0.70, 3.63) | 21.2 | 1.46 (0.74, 3.17) | 6.7 |
| Bisphenol S (BPS) | 0.36 (0.17, 1.07) | 32.0 | 0.24 (0.12, 0.49) | 71.0 |
| Bisphenol F (BPF) | 0.58 (0.30, 1.31) | 59.8 | 0.50 (0.31, 1.22) | 88.3 |
| Phthalic acid (PA) metabolites | 57.44 (31.09, 123.62) | 0.3 | 149.79 (61.83, 280.49) | 0.1 |
| Low molecular weight (LMW) metabolitesa | 1076.70 (422.84, 2953.02) | 586.84 (237.99, 1460.35) | ||
| Monomethylphthalate (mMP) | 5.59 (2.76, 9.82) | 0.2 | 3.46 (1.84, 6.21) | 0.2 |
| Monoethylphthalate (mEP) | 135.20 (41.02, 489.33) | 0.1 | 72.84 (25.06, 224.04) | - |
| Mono-isobutylphthalate (mIBP) | 20.97 (9.55, 45.43) | 0.2 | 8.86 (4.58, 17.81) | - |
| Mono-n-butylphthalate (mBP) | 15.99 (7.02, 31.03) | 0.8 | 9.66 (5.45, 18.97) | - |
| High molecular weight (HMW) metabolitesa | 217.41 (112.57, 403.02) | 130.83 (73.78, 242.34) | ||
| Di-2-ethylhexylphthalate (DEHP) metabolitesa | 171.36 (89.19, 318.69) | 96.46 (53.06, 182.92) | ||
| Mono-(2-ethyl-5-carboxypentyl)phthalate (mECPP) | 16.04 (8.23, 31.25) | 0.2 | 10.42 (5.75, 19.95) | 0.1 |
| Mono-(2-ethyl-5-hydroxyhexyl)phthalate (mEHHP) | 11.78 (5.76, 22.59) | 0.2 | 5.57 (2.94, 10.65) | 0.1 |
| Mono-(2-ethyl-5-oxohexyl)phthalate (mEOHP) | 7.67 (3.54, 15.28) | - | 7.43 (3.65, 16.11) | - |
| Mono-[(2-carboxymethyl)hexyl]phthalate (mCMHP) | 14.03 (7.60, 26.25) | 0.1 | 4.01 (2.28, 7.32) | 0.3 |
| Di-isononylphthalate (DINP) | ||||
| Monoisononylphthalate (mINP) | 0.74 (0.36, 1.93) | 86.2 | 0.74 (0.36, 1.93) | 98.7 |
| Di-isodecylphthalate (DIDP) | ||||
| Mono-(8-methyl-1-nonyl)phthalate (MIDP) | 1.80 (1.28, 2.73) | 92.0 | 1.80 (1.28, 2.73) | 98.2 |
| Di-n-octylphthalate (DNOP)a | 5.77 (3.16, 10.81) | 3.53 (2.05, 6.74) | ||
| Mono(3-carboxypropyl)phthalate (mCPP) | 1.45 (0.80, 2.75) | 0.3 | 0.89 (0.52, 1.69) | - |
| Monooctylphthalate (mOP) | 0.46 (0.34, 0.79) | 90.3 | 0.46 (0.34, 0.79) | 99.4 |
| Mono-(7-carboxy-n-heptyl)phthalate (mCHpP) | 0.11 (0.08, 0.13) | 99.2 | 0.11 (0.08, 0.13) | 100.0 |
| Other high molecular weight metabolites | ||||
| Monobenzylphthalate (mBzP) | 6.35 (3.05, 12.55) | 8.1 | 5.22 (2.26, 11.03) | 1.5 |
| Mono-hexylphthalate (mHxP) | 0.33 (0.16, 0.62) | 24.2 | 0.33 (0.16, 0.62) | 98.7 |
| Mono-2-heptylphthalate (mHpP) | 1.09 (0.59, 2.33) | 35.2 | 1.09 (0.58, 2.33) | 96.7 |
| Monocyclohexylphthalate (mCHP) | 0.17 (0.09, 0.42) | 80.9 | 0.17 (0.09, 0.42) | 94.3 |
a
Groups are molar concentrations in nmol/L with non-detectable levels of separate metabolites imputed as LOD/sqr(2). Separate metabolites are included only if less than 80% of values was below the LOD. GA : gestational age.