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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Brain Behav Immun. 2020 Jul 24;89:414–422. doi: 10.1016/j.bbi.2020.07.028

Figure 2. Experiment 1: Chemogenetic inactivation of dHpc output regions dSub and dCA1 disrupts expression of heroin contextually conditioned suppression of NO.

Figure 2.

Experimental timeline (A). DREADD (mCherry) expression as a composite of all subjects (B). Effect of CNO administration on plasma nitrate/nitrite concentration (C) and splenic iNOS mRNA (D) and protein (E) expression following heroin-paired context exposure and LPS challenge. CS = heroin-paired contextual conditioned stimulus, HC = home cage; *, statistically significant difference relative to respective HC control. ‡, statistically significant difference relative to Vehicle/CS group.