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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Brain Behav Immun. 2020 Jul 24;89:414–422. doi: 10.1016/j.bbi.2020.07.028

Figure 3. Experiment 2: Chemogenetic inactivation of vHpc output regions vSub and vCA1 does not disrupt expression of heroin contextually conditioned suppression of NO.

Figure 3.

Experimental timeline (A). DREADD (mCherry) expression (B). Effect of CNO administration on plasma nitrate/nitrite concentration (C) and splenic iNOS mRNA (D) and protein (E) expression following heroin-paired context exposure and LPS challenge. CS = heroin-paired contextual conditioned stimulus, HC = home cage; *, statistically significant difference relative to respective HC control. ‡, statistically significant difference relative to Vehicle/HC group.